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Ultra Low Variant Detection: Du Novo Sequencing

Du Novo Sequencing can achieve sub-1% variant detection, which improves on other Duplex Sequencing analysis tools by removing reliance on a reference sequence, preserving a higher proportion of the input reads, and being available for Galaxy. We demonstrate the application of this approach by validating rare variants in the human mitochondrial genome. Dr. Barbara Arbeithuber (Johannes Kepler University Linz, Center for Medical Research) and Dr. Nick Stoler (Penn State University) will present the method and applications in this webinar.

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